Table 3.
Top 10 genes evaluated in the PPI network using five calculation methods and employing CytoHubba in Cytoscape. The overlapping hub genes in the top 10 by five ranked methods respectively in cytoHubba are highlighted in bold.
| Gene | MCC | Gene | MNC | Gene | Degree | Gene | EcCentricity | Gene | EPC |
|---|---|---|---|---|---|---|---|---|---|
| VEGFA | 610.0 | JUN | 25.0 | JUN | 26.0 | JUN | 0.17375 | VEGFA | 28.994 |
| JUN | 609.0 | VEGFA | 24.0 | VEGFA | 26.0 | VEGFA | 0.17375 | JUN | 28.507 |
| FGF2 | 434.0 | CCND1 | 20.0 | TLR4 | 23.0 | TLR4 | 0.17375 | CCND1 | 27.439 |
| CCND1 | 382.0 | TLR4 | 20.0 | CCND1 | 22.0 | FGF2 | 0.17375 | TLR4 | 26.957 |
| CDKN1A | 357.0 | FGF2 | 17.0 | FGF2 | 17.0 | LGALS3 | 0.17375 | FGF2 | 26.208 |
| TLR4 | 285.0 | CDKN1A | 16.0 | CDKN1A | 17.0 | BIRC3 | 0.17375 | CDKN1A | 26.047 |
| ITGAM | 245.0 | ITGAM | 16.0 | ITGAM | 17.0 | CXCR4 | 0.17375 | ITGAM | 24.942 |
| AURKB | 216.0 | AURKB | 13.0 | PRKACA | 15.0 | DDX58 | 0.17375 | LGALS3 | 22.287 |
| PSMB8 | 202.0 | PSMB8 | 10.0 | AURKB | 13.0 | HSPB3 | 0.17375 | CXCR4 | 22.271 |
| PSMD12 | 198.0 | THY1 | 10.0 | PSMB8 | 12.0 | ABCB1 | 0.17375 | BIRC3 | 21.898 |
MCC: Maximal Clique Centrality, MNC: Maximum Neighborhood Component, EPC: Edge Percolated Component.