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The TpH1–5-HT pathway in the brain of the combined group. (A,B) Volcano plot and heatmap of the differentially expressed proteins. (C) Associated signaling pathways. (D) Comparison of 5-HT expression among the SBI, BP, and combined groups at 1, 3, 7, and 14 days. (E) The rate-limiting enzyme TPH in the colon, small intestine, and brain. *p < 0.05, **p < 0.01.
