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. 2021 May 18;296:100789. doi: 10.1016/j.jbc.2021.100789

Figure 4.

Figure 4

Sequence comparison between SLC35A1 and SLC35A4.A, sequence alignments between human and mouse SLC35A1 (CST) as well as human and mouse SLC35A4. The blue shading indicates the degree of residue conservation. The yellow bars under the sequences indicate the location of the indicated transmembrane (TM) domain. The interfacial alpha helix (IH) connecting TMs 2 and 3 is also indicated. The alignments were done using Jalview using a threshold of 40% to indicate the degree of residue conservation. B, the structure of mCST in complex with CMP-sialic acid is shown as a cartoon representation with the CMP-sialic acid shown as yellow sticks. The blue coloring indicates the degree of residue conservation in the same manner as in the sequence alignment in panel A. The top is the Golgi-facing side of the protein, whereas the bottom faces the cytoplasm. mCST, mouse CMP-sialic acid transporter.