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. 2021 Jun 10;4:713. doi: 10.1038/s42003-021-02251-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Lateral view of C57BL/6 mice (n = 3/experimental group and n = 2/control group), immunized i.m. with 5 × 10⁷ TU of LV-CMV-nLuc, LV-β2m-nLuc, or LV-GFP as a negative control. Furimazine substrate (4 mg/kg) was injected i.p. right before imaging at 5, 7, 9, 12, and 14 dpi. Bioluminescence images indicate the location of nLuc. b Mean bioluminescence signal in C57BL/6 mice immunized i.m. with 5 × 10⁷ TU of LV-CMV or LV-β2m encoding nLuc. c Representative bioluminescence images of tissues and organs of C57BL/6 mice (n = 3/experimental group and n = 2/control group) at 5 dpi with 5 × 10⁷ TU of LV-CMV-nLuc, LV-β2m-nLuc, or LV-GFP as a negative control. LN lymph node. d Lateral view of C57BL/6 mice (n = 5) immunized i.m. with 5 × 10⁷ TU of LV-β2m-nLuc and was imaged at 3, 4, 5, 6, 7, and 12 dpi. e The mean bioluminescence signals of mice immunized with LV-β2m-nLuc. For (b) and (e), the dotted line represents the background level determined from mice immunized with LV-GFP and had received furimazine substrates upon imaging. Each point represents the mean bioluminescence signal (p/s/cm²/sr) per group, expressed as mean ± SEM. Smaller dots represent biological replicates.