Figure 3.

Associations between the SARS-CoV-2-specific B cell memory and CD4⁺ T cell functions in recovered individuals

(A) Heatmaps demonstrate the strength of correlations between the CD4⁺ T cell functions and parameters determining quantity and quality of S1-specific memory B cell response. Each heatmap shows CD4⁺ T cell response specific for one of the three proteins. Cells are color-coded concerning Spearman’s correlation coefficient. Significant correlations are marked by asterisks.

(B) Heatmaps depicting correlations between the magnitude of CD4⁺ T cell helper functions and determinants of humoral response, including levels of S1-specific IgG, IgA, and neutralization capacity. Each heatmap shows CD4⁺ T cell response specific for one of the three proteins. The number of independent experiments represented in the above graphs is n = 18. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.

See also Figure S1.