Figure 6.

Memory phenotype of B cells in severely ill ICU patients

(A) Graphs demonstrate proportions of memory subsets within bulk and S1-specific memory B cell populations in comparison with the healthy control.

(B) Compared are the frequencies of memory B cell subsets between the severely ill and recovered individuals for bulk IgG⁺ and S1⁺ IgG⁺ memory B cell populations. The number of independent experiments is n = 8 for the healthy group, n = 11 for the severely ill group, and n = 18 for the recovered group. Data are presented as mean ± SD. Differences between the groups were assessed using the Mann-Whitney test or Wilcoxon test for matched data.

(C) Correlation maps show associations between CD4⁺ T cell functions and memory phenotype of S1⁺ memory B cells. Each map shows the CD4⁺ T cell response specific for one of the three proteins. Cells are color-coded concerning Spearman’s correlation coefficient. Significant correlations are marked by asterisks. The number of independent experiments is n = 11. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.