Table 1.
Pluripotency-related TF in PSCs and CSCs
| Pluripotency marker | Role in cancer development | Type of Cancer | References |
|---|---|---|---|
| OCT4 | Stemness, EMT, Metastasis and drug resistance | Breast cancer | [168–170] |
| Pancreatic cancer | [171] | ||
| Liver cancer | [172] | ||
| SOX2 | Stemness, EMT, Metastasis and drug resistance | Squamous cell carcinoma | [90, 173] |
| Small cell lung carcinoma | [91] | ||
| Non- Small cell lung carcinoma | [174] | ||
| Glioblastoma | [175] | ||
| Colorectal cancer | [176] | ||
| Bladder Urothelial carcinoma | [93] | ||
| Osteosarcoma | [94] | ||
| Tumor suppressor | Colorectal cancer | [95] | |
| Neuroblastoma, | [96] | ||
| Nasopharyngeal sarcoma | [97, 177] | ||
| NANOG | Stemness, EMT, Metastasis and drug resistance | Glioblastoma | [86] |
| Liver | [87, 178] | ||
| Colorectal cancer | [88] | ||
| Prostate cancer | [89, 179] | ||
| Gastric cancer | [180] |