Table 4.

Reclassification of hemorrhagic transformation by circulating biomarkers among ischemic stroke patients.

Models	C statistics		Category-free NRI		IDI
	Estimate (95% CI), %	P-value	Estimate (95% CI), %	P-value	Estimate (95% CI), %	P-value
Conventional model	0.78 (0.75–0.81)	Reference	Reference	Reference	Reference	Reference
Conventional model + PLT	0.79 (0.76–0.82)	0.115	49.3% (33.4%–65.2%)	<0.001	2.1% (0.8%–3.3%)	0.002
Conventional model + NLR	0.79 (0.75–0.82)	0.062	34.5% (18.6%–50.4%)	<0.001	1.0% (−0.2%–2.1%)	0.102
Conventional model + HDL	0.78 (0.75–0.82)	0.573	31.7% (15.8%–47.6%)	<0.001	1.4% (0.3%–2.5%)	0.013
Conventional model + multi-marker score	0.80 (0.77–0.83)	0.010	56.2% (40.4%–72.1%)	<0.001	3.2% (1.4%–5.0%)	0.001
Conventional model + all three biomarkers	0.80 (0.77–0.83)	0.012	65.6% (49.7%–81.4%)	<0.001	3.0% (1.5%–4.6%)	<0.001<

Abbreviations: CI; confidence interval; NRI, net reclassification improvement; IDI, integrated discrimination index; PLT, Platelet; NLR, Neutrophil-to-lymphocyte Ratio; Conventional model included age, sex, atrial fibrillation, National Institutes of Health Stroke Scale score, smoking, drinking, systolic blood pressure, antiplatelets, lipid-lowering agents, endovascular treatment (Thrombolysis/Thrombectomy) and the Trial of ORG 10172 in Acute Stroke Treatment.