Fig. 8.

OXA Derivative Screen against Schistosoma sp. in vitro. OXA derivatives CIDD-00149830, a racemic derivative of OXA and CIDD-0072229, R-enantiomer of CIDD- 0066790 were tested against adult male Schistosoma worms in vitro. All derivatives were solubilized in 100% DMSO and administered at a final concentration of 143 μM per well. All screens were performed in experimental and biological triplicate. Survival was plotted as a percentage over time using the Kaplan-Meier curves. Pair wise comparison was performed using a log-rank test with Bonferroni correction for multiple testing. The p-value threshold for each derivative compared to DMSO was <0.001. Green was S. mansoni, purple S. japonicum, gold S. haematobium, red oxamniquine, a positive control against S. mansoni and black a negative control DMSO. Solid lines are CIDD-00149830, dashed lines are CIDD-0072229. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)