Table 5.
DMM overlap with up-regulated DEGs.
| Gene name | Gene symbol | gene ontology terms of biological processes (selected) | mRNA regulation Log2-fold change |
|---|---|---|---|
| apolipoprotein E | APOE | response to reactive oxygen species | 2.963896 |
| tenascin C | TNC | positive regulation of cell proliferation | 2.817838 |
| solute carrier family 12 member 8 | SLC12A8 | ion transport | 2.447643 |
| JunB proto-oncogene | JUNB | vasculogenesis | 1.9883 |
| adrenomedullin | ADM | vasculogenesis | 1.909539 |
| elastin microfibril interfacer 1 | EMILIN1 | aortic valve morphogenesis | 1.54932 |
| pleckstrin homology domain containing A4 | PLEKHA4 | phosphatidylinositol biosynthetic process | 1.544703 |
| ras homolog family member G | RHOG | actin filament organization | 1.415065 |
| matrix metallopeptidase 14 | MMP14 | angiogenesis | 1.358464 |
| complement C1r | C1R | regulation of complement activation | 1.357514 |
| ribosome binding protein 1 | RRBP1 | osteoblast differentiation | 1.253301 |
| protein phosphatase 1 regulatory subunit 18 | PPP1R18 | cytoplasm | 1.061758 |
DMM, differentially methylated N6-methyladenosine; DEGs, differential expressed genes. Differentially methylated N6-methyladenosine overlap with up-regulated differential expressed genes. Multiple genes are involved in the positive regulation of extracellular matrix organization and cell proliferation.