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. 2021 May 28;12:693777. doi: 10.3389/fphar.2021.693777

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Copyright © 2021 Ling, Yang, Hua, Wang, Zhao, Weng, Yue, Cai, Meng, Chen, Sun, Kong, Zhu, Cao and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZJS delayed the onset of arthritis and ameliorated arthritis severity in CIA mice. (A) Experimental scheme of the analysis of CIA mice. (B) Incidence of arthritis in each group was determined (n = 7). (C) Changes in the arthritis score were assessed in each group (n = 7). (D) Changes in the hind paw swelling were measured in each group (n = 7). (E) Changes in the paw withdrawal threshold were detected in each group using von Frey filaments (n = 7). (F) Changes in body weight were measured in each group (n = 7). (G) Representative images of the ankle joints of the mice taken on day 51 from the experiment in the indicated groups. Values are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001, compared with the vehicle group (Two-way ANOVA test).