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. 2021 May 28;12:693777. doi: 10.3389/fphar.2021.693777

FIGURE 6.

FIGURE 6

ZJS suppressed the RANKL-induced NF-κB signaling pathway. (A) Representative immunoblots of p65 and p-p65 in BMMs were performed by western blotting, β-actin was used as the internal reference protein. (B) Representative immunofluorescence images of p65 in the nucleus of BMMs in the indicated groups (scale bars = 10 μm). (C) Representative immunoblots of NFATc1, c-Fos, cathepsin K, and MMP9 in BMMs were performed by western blotting, β-actin was used as the internal reference protein. (D) Western blot analysis of p-p65 in BMMs in the indicated groups (n = 3). (E) Western blot analysis of NFATc1, c-Fos, cathepsin K, and MMP9 in BMMs in the indicated groups (n = 3). Values are presented as the mean ± SEM. # p < 0.05, ## p < 0.01, #### p < 0.001, compared with the RANKL-untreated group. *p < 0.05, **p < 0.01, ****p < 0.001, compared with the RANKL + ZJS-untreated group (One-way ANOVA test).