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Location of 10 GNAO1 variants in the Gαo amino acid sequence. All variants are indicated corresponding to their locations within the gene. Variants with asterisks had been reported previously, and those with triangles are hotspot variants. Different background color of the box represents different phenotypes (orange: EIEE, early infantile epileptic encephalopathy; green: MD, movement disorder; blue: EIEE and MD; yellow: DD, development delay).
