FIGURE 3.

Role of Kv1.3 in postoperative cognitive decline in the trace fear-conditioning (TFC) paradigm. Applied for Permission to Reproduce Ieng et al. (2020). Cohorts of mice were trained in a TFC paradigm immediately before surgery and tested for freezing behavior 3 days after surgery. (A) Wild-type mice (12-14 weeks old C57bl/6j) were randomized to three groups (n = 8–9 per group) that received no surgery/vehicle, surgery/vehicle, or surgery/phenoxyalkoxypsoralen-1 (PAP-1). (B) Wild-type mice with diet-induced obesity (DIO) were randomized to three groups (n = 8–10 per group) that received no surgery/vehicle, surgery/vehicle, or surgery/PAP-1. (C) Mice deficient in Kv1.3 (Kv1.3–/–) were randomized to two groups (n = 910 per group) that received either sham (no surgery) or surgery. After wound closure and every 12 h thereafter, the mice randomized to PAP-1 received 40 mg kg¹ i.p. vehicle consisted of MIGLYOL in the same volume as PAP-1. On the third day, freezing behavior was tested in the same context as the training. (A,B) Analyzed by one-way analysis of variance followed by Bonferroni post hoc test. (C) Analyzed by unpaired t-test. *P1/40.029; **P1/40.005; xP1/40.011; xxP1/40.030 (Ieng et al., 2020).