Fig. 5.

In vitro drug permeation from the nanocrystalline formulation (red), amorphous aprepitant (blue), amorphous aprepitant in the presence of HPMC (green), DES formulation (orange), DES formulation in the presence of HPMC (purple). All formulations were tested with a concentration of 150 μg/mL in the donor compartment corresponding to the 3 mg dose in the drug release studies. Error bars represent standard deviations. n = 4. Data points below the LOQ have been excluded. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)