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Pharmacokinetic study design.
| Formulation | Average body weight (g) | Animals (n) | Dose (mg/kg bw) | Dose volume (mL/kg) | Dose volume (mL) |
|---|---|---|---|---|---|
| IV | 340 ± 2 | 3 | 2.00 | 1.20 | 0.41 |
| Nanocrystals | 344 ± 7 | 5 | 2.40 | 5.00 | 1.72 |
| Amorphous form | 343 ± 7 | 5 | 2.40 | 5.00 | 1.72 |
| DES formulation | 350 ± 10 | 5 | 2.40 | 0.43 | 0.14 |
| DES formulation with 10 wt% HPMC | 357 ± 11 | 5 | 2.40 | 0.47 | 0.16 |
