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. 2021 May 28;15:673600. doi: 10.3389/fnins.2021.673600

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Copyright © 2021 Žigman, Petković Ramadža, Šimić and Barić.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the methionine metabolism according to Barić et al. (2017), slightly modified. 5-MTHF, 5-methyltetrahydrofolate; ADK, adenosine kinase; AdoHcy, S-adenosylhomocysteine; AdoMet, S-adenosylmethionine; AMP, adenosine monophosphate; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine β-synthase; GNMT, glycine N-methyltransferase; dTMP, 2′-deoxythymidine-5′-monophosphate (thymidylate); dUMP, 2′-deoxyuridine-5′-monophosphate; MAT, methionine adenosyltransferase; MS, methionine synthase; MTHFR, methylenetetrahydrofolate reductase; MTs, a variety of AdoMet-dependent methyltransferases; THF, tetrahydrofolate; SAHH, S-adenosylhomocysteine hydrolase; TS, thymidylate synthase.