Table 1.
Endogenous and exogenous ligands of TRPV1.
| Ligands | Ref. |
|---|---|
| Endogenous agonists: | |
| Anandamide | 25 |
| N-arachidonoyldopamine | 26 |
| N-oleoyldopamine | 27 |
| R(+)-methanandamide | 25 |
| 12- and 15-hydroperoxyeicosatetraenoic acid | 28 |
| 5- and 15-hydroxyeicosatetraenoic acid | 28 |
| Leukotriene B4 | 28 |
| 9- and 13-hydroxy-octadecadienoic acid | 12 |
| 9- and 13-oxo-octadecadienoic acid | 12 |
| Oleoylethanolamide | 29 |
| Palmitoylethanolamide | 30 |
| Lysophosphatidic acid | 31 |
| Oxytocin | 32 |
| Exogenous agonists | |
| 2-aminoethoxydiphenyl borate | 33 |
| 4α-phorbol-12,13-didecanoate | 34 |
| Ornithoctonus huwena toxin ['double-knot' toxin (DkTx)] | 35 |
| Capsaicin | 8 |
| Piperine | 36 |
| Resiniferatoxin | 37 |
| Gingerol | 38 |
| Evodiamine | 39 |
| Cannabidiol | 40 |
| Cannabigerol | 41 |
| Polygodial | 42 |
| Vanillotoxin | 43 |
| MD-652 | 44 |
| Linopirdine | 45 |
| Endogenous antagonists | |
| Resolvin D2 | 46 |
| Noradrenaline | 47 |
| Exogenous antagonists | |
| Capsazepine | 48 |
| Iodo-resiniferatoxin | 49 |
| Hypericum perforatum | 50 |
| JNJ-17203212 | 51 |
| BCTC | 52 |
| Thapsigargin | 53 |
| Yohimbine | 54 |
| JYL 1421 | 55 |
| Caffeic acid | 56 |
| Asivatrep | 57 |
| SB-366791 | 58 |
| A-1165442 | 59 |
| AMG 9810 | 60 |
| AG489, AG505 | 61 |
| ABT-102, AMG-517, AZD-1386, DWP-05195, GRC-6211, JTS-653, MK-2295, PHE377, SB-705498 | 62, 63 |