Table 1.
Current GLP-1RAs in the clinic
| GLP-1RAs | Classification | Frequency of administration | Half-life (t1/2) |
|---|---|---|---|
| Lixisenatide | Short-acting | Once daily | 3 h |
| Oral semaglutide | Short-acting | Once daily | ≈1 week |
| Exenatide | Short-acting Long-acting |
Twice daily/ Once weekly |
2.4 h/Sustained-release |
| Liraglutide | Long-acting | Once daily | 13 h |
| Semaglutide | Long-acting | Once weekly | ≈1 week |
| Albiglutide | Long-acting | Once weekly | ≈5 days |
| Taspoglutide | Long-acting | Once weekly | ≈1 week |
| Dulaglutide | Long-acting | Once weekly | 4.5-4.7 days |