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. 2021 May 5;17(8):1895–1908. doi: 10.7150/ijbs.59855

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Changes in the expression of various proteins in signaling pathways following PKM2 inhibition by compound 3K for 24 h. (A) The effect of PKM2 inhibition on signaling pathways in SK-OV-3 cells. Cells were treated with compound 3K, and western blot analysis was conducted to determine the expression levels of various signaling pathway proteins. (B) The band intensity of Akt, p-Akt, AMPK, p-AMPK, mTOR, p-mTOR, p70S6K, and p-p70S6K were calculated and expressed in the graph as a ratio of β-actin. The values represent the mean ± SD. *p < 0.05 and **p < 0.01.