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. 2021 May 5;17(8):1895–1908. doi: 10.7150/ijbs.59855

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Compound 3K inhibited SK-OV-3 cell tumorigenesis in vivo. Compound 3K exhibited therapeutic effect on ovarian cancer in a tumor xenograft model. BALB/c nude mouse were divided into two groups randomly (n = 5 per group) and administered with vehicle or compound 3K (5 mg/kg) orally. Tumor size was calculated every three days for 31 days before the mice were sacrificed. (A) Changes in tumor volume. (B) Photographs of the tumors. (C) Comparison of tumor weight between compound 3K group and control group. (D) Changes of body weight. (E) Immunohistochemical analysis using an anti-Ki-67 antibody and its quantification (Magnification ×100). The values represent the mean ± SD. *p < 0.05 and **p < 0.01.