Table 3.
Summary of driver gene expression in GBM molecular subtypes in the 10–29 year subgroup with significant p-value. Data represent mean ± standard deviation for z-score in each gene. Statistical significance is represented by asterisks.
| young subgroup (10–29 years) | proneural | classical |
|---|---|---|
| DNA repair and chromatin remodelling genes | ||
| ATRX | 0.105 ± 1.316 | −0.105 ± 0.711 |
| BRAF | 0.257 ± 0.466 | 0.034 ± 0.777 |
| H3F3A | 0.375 ± 0.626 | −0.202 ± 0.619 |
| MGMT | 0.297 ± 0.494 | 0.176 ± 1.782 |
| TERT | 0.066 ± 0.335 | 0.196 ± 0.464 |
| cytoskeleton and cellular proliferation genes | ||
| EGFR | −3.133 ± 1.228 | −4.563 ± 2.382 |
| FLT1 | −0.946 ± 0.61 | −0.955 ± 0.539 |
| GFAP | −0.106 ± 0.914 | 0.262 ± 0.113 |
| IDH1 | −0.679 ± −0.679 | −0.910 ± 0.204 |
| MKI67 | 0.820 ± 2.157 | 0.572 ± 1.801 |
| NES | −0.207 ± 1.018 | 0.822 ± 1.167 |
| OLIG2 | 0.998 ± 1.427 | −1.341* ± 0.859 |
| PIK3CA | 0.058 ± 0.526 | 0.272 ± 0.844 |
| S100A1 | 0.452 ± 1.032 | 0.101 ± 0.807 |
| SMAD3 | 0.104 ± 0.732 | 0.664 ± 0.438 |
| VIM | −1.127 ± 1.343 | 1.455* ± 0.353 |
| tumour suppressor genes | ||
| SMARCB1 | 0.830 ± 0.653 | 0.653 ± 0.874 |
| TP53 | 0.286 ± 0.993 | −0.336 ± 1.242 |
*p < 0.05, **p < 0.01 and ***p < 0.001.