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. 2021 May 28;12:668765. doi: 10.3389/fphar.2021.668765

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Copyright © 2021 Khouri, Nguyen, Revol, Lepelley, Pariente, Roustit and Cracowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted probability for a signal of disproportionate reporting (SDR) to correspond to a true ADR according to the lower boundary of disproportionality values and to the number of positive SDR. Results of all models according to number of positive SDR for ROR_LB and IC_LB are presented in A, B respectively. Results of model 1 according to the number of positive SDR for ROR_LB and IC_LB are presented in C, D. Model 1: only suspect cases included; Model 2: subgroup by country (United States); Model 3: reporting by health professionals only; Model 4: subgroups by therapeutic area; Model 5: serious cases only; Model 6: within 5 years of drug approval; Model 7: suspected and concomitant drugs.