Table 1. Characteristics of All 80 Patients at Study Entry.
| Characteristic | No. (%) |
|---|---|
| Age, median (range), y | 65 (26-83) |
| ≥65 | 43 (54) |
| Sex | |
| Female | 23 (29) |
| Male | 57 (71) |
| Rai stage | |
| III-IV | 41 (51) |
| Baseline laboratory test results, median (range) | |
| ALC, ×109/L | 75.6 (1.1-338) |
| Hemoglobin, g/dL | 11.6 (7.7-15.8) |
| Platelet count, ×109/L | 130 (28-334) |
| Serum β2-microglobulin, mg/L | 3.5 (1.7-13.7) |
| Hierarchical fluorescence in situ hybridization | |
| Del(17p) | 14 (18) |
| Del(11q) | 20 (25) |
| Trisomy 12 | 17 (21) |
| Normal | 10 (12) |
| Del(13q) | 19 (24) |
| IGHV status | |
| No. | 76 |
| Unmutated | 63 (83) |
| Mutated | 13 (17) |
| Cytogenetics | |
| No. | 78 |
| Complex (≥3 abnormalities) | 12 (15) |
| Diploid | 32 (41) |
| Gene alteration | |
| No. | 79 |
| TP53 | 11 (14) |
| NOTCH1 | 22 (28) |
| SF3B1 | 18 (23) |
| BIRC3 | 5 (6) |
Abbreviations: ALC, absolute lymphocyte count; IGHV, immunoglobulin heavy-chain variable.
SI conversion factor: To convert hemoglobin to grams per liter, multiply by 10.