Table 2. Nonhematologic Adverse Events That Occurred in 5% or More of the Patients.
| Event | Patients, No. (%) | |
|---|---|---|
| Any grade | Grade ≥3 | |
| Easy bruising | 61 (76) | 0 |
| Arthralgia | 46 (58) | 2 (2) |
| Diarrhea | 42 (53) | 0 |
| Nausea/vomiting | 33 (41) | 0 |
| Myalgia | 28 (35) | 1 (1) |
| Skin rash | 19 (24) | 0 |
| Nail changes | 16 (20) | 0 |
| Fatigue | 15 (19) | 1 (1) |
| Gastroesophageal reflux disease | 14 (18) | 0 |
| Hypertension | 13 (16) | 8 (10) |
| Atrial fibrillation/flutter | 12 (15) | 8 (10) |
| Oral mucositis | 12 (15) | 0 |
| Dry skin | 11 (14) | 0 |
| Constipation | 8 (10) | 0 |
| Increased creatinine level | 7 (9) | 0 |
| Headache | 6 (8) | 0 |
| Epistaxis | 6 (8) | 0 |
| Increased alanine aminotransferase level | 5 (6) | 1 (1) |