Table 2.
Sleep characteristics for db/db mice transfected with either Ad-mCherry or Ad-LepRb and infused with PBS or leptin ICV
| n | Sleep efficiency, % | Sleep time, min | Sleep Bout number, n | Sleep Bout length, s | |||||
|---|---|---|---|---|---|---|---|---|---|
| TST | NREM | REM | NREM | REM | NREM | REM | |||
| Ad-mCherry | |||||||||
| PBS | 12 | 73.6 ± 4.3 | 273.0 ± 17.6 | 268.6 ± 17.2 | 4.5 ± 2.2 | 41.9 ± 4.9 | 4.7 ± 2.1 | 486.2 ± 96.9 | 44.2 ± 10.5 |
| Leptin | 12 | 72.3 ± 4.0 | 281.2 ± 20.5 | 274.8 ± 21.1 | 6.5 ± 1.4 | 31.4 ± 6.0 | 5.5 ± 1.0 | 446.8 ± 91.9 | 72.5 ± 10.4 |
| Ad-LepRb | |||||||||
| PBS | 14 | 64.3 ± 3.7 | 241.0 ± 16.6 | 235.9 ± 16.5 | 5.2 ± 0.8 | 57.8 ± 5.3 | 5.0 ± 0.7 | 301.0 ± 50.9 | 65.9 ± 4.9 |
| Leptin | 14 | 69.6 ± 3.9 | 267.1 ± 19.1 | 266.1 ± 19.2 | 1.0 ± 0.3*** | 58.5 ± 8.3 | 1.3 ± 0.4*** | 447.6 ± 115.6 | 34.2 ± 9.6 |
Values presented as mean values ± standard error.
ICV, intracerebroventricular; TST, total sleep time.
***p < 0.001.