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. 2021 Jun 9;218(8):e20202489. doi: 10.1084/jem.20202489

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© 2021 Viant et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure S3. — Gene expression profiles of GC-Bmem and Act-Bmem cells are distinct. Related to Fig. 3. (A) Gating strategy used for purifying ZSGreen⁻ (ZSG⁻) mCherry^hi follicular (Fo) B cells, ZSG⁺ Act B cells, ZSG⁺ mCherry^low GC cells, ZSG⁺ GC-Bmem cells, and ZSG⁺ Act-Bmem cells. (B) Heat map shows hierarchical clustering based on expression of 16 expressed genes in Reactome class A 1 Rhodopsin-like receptors and Reactome GPCR binding; 21 expressed genes in hallmark E2F targets; 45 expressed genes in Reactome signaling by interleukins and Reactome cytokine in immune system; and 49 expressed genes in Reactome cell cycle, Reactome cell cycle checkpoints, Reactome cell cycle mitotic, and Reactome M phase by Fo, GC, and activated B cells (Act B cell) and Act-Bmem and GC-Bmem cells. Dox, doxycycline; TAM, tamoxifen.