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. 2021 May 25;21(11):4765–4773. doi: 10.1021/acs.nanolett.1c01236

Figure 4.

Figure 4

Cell-to-cell accessibility assessed by multicellular assembly driven by cell-surface ssDNA and ssDNA-comp. Two groups of color-coded HUVECs with surface decoration of mutually complementary ssDNA and ssDNA-comp were mixed at a ratio of 1:100 (green:red) for DNA-guided multicellular assembly. (a, b) Assembly between cell groups with PLB-anchored ssDNA and ssDNA-comp initiators in the absence (a) and presence (b) of the DNA duplex bridge on the green cells. (c, d) Assembly between cell groups with glycocalyx-anchored ssDNA and ssDNA-comp initiators in the absence (c) and presence (d) of the DNA duplex bridge on the green cells. (e) Quantification of the number of peripheral cells per central cell in the resulting assemblies. Data represent means ± s.d. from three independent replicates. ***P ≤ 0.001.