Table 2.
Effect of γ-Radiation Exposure and/or Zinc Oxide–Caffeic Acid Nanoparticles Treatment on the Tumor Volume and Weight of Solid Ehrlich Bearing Mice.
| Groups | Tumor volume (cm³) | Tumor weight (g) | |
|---|---|---|---|
| Third week (21 days) | Fourth week (28 days) | ||
| E# | |||
| Mean ± SE | 1.19 ± 0.14 a | 1.91 ± 0.14 a | 5.7 ± 0.32 a |
| E+R@ | |||
| Mean ± SE | 1.13 ± 0.10 a | 1.6 ± 0.14 a | 5.3 ± 0.33 a |
| % Change | −5.04 | −16.23 | −7.0 |
| E+ZnO-CA# | |||
| Mean ± SE | 0.41 ± 0.06 b | 0.88 ± 0.14 b | 2.5 ± 0.16 b |
| % Change | −65.55 | −53.93 | −56.1 |
| E+ZnO-CA+R | |||
| Mean ± SE | 0.24 ± 0.04 b | 0.43 ± 0.07 c | 1.6 ± 0.12 c |
| % Change | −79.83 | −77.49 | −71.9 |
| F-ratio | 25.13 | 28.62 | 66.24 |
Results are mean of 11-12 mice ± SE; @n = 11, and #n = 12 (one mouse out of 12 died in animals bearing solid Ehrlich (EC) tumor that were either irradiated only or co-administered ZnO-CA NPs along with gamma (γ)-irradiation). Values with dissimilar superscripts are significantly different. E: Solid EC bearing mice, R: mice exposed to 2 Gy of whole body γ-irradiation/week, for 3 consecutive weeks, and ZnO-CA: mice injected intraperitoneally with 5 mg/100 g body weight ZnO-CA NPs, every other day for 3 consecutive weeks. %Change versus E. P-value < 0.001.