Figure 9.

A tumor with intermediate DR (1). Keloid-like, hyalinized collagen bundles are observed at the desmoplastic front. Note that some keloid-like collagen is located adjacent to the cancer nests, and some is located distant from the cancer nests (Figure 10), depending on the individual tumors. In this case, keloid-like collagen is distributed close to the cancer nests as if coiled around them. (B; ×4 objective) and (C; ×10 objective) are magnifications of the desmoplastic front, as indicated by the arrow in (A) (whole slide image). Insert in (C), ×20 objective. All, H&E staining.