Figure 5.

The effect of genome mutation on miRNA repositories and function.

A: The comparison between the MFE of hairpin folding of candidate miRNAs derived from the wild type and mutated SARS-CoV-2 genome (n=33). B: The overlap of the putative miRNAs binding to the wild type and mutant genome. C: The functional annotation of genes targeted by miRNAs specifically binding to the mutant SARS-CoV-2 genome. D: The functional annotation of genes targeted by miRNAs specifically binding to the wild-type SARS-CoV-2 genome. Two-sided Wilcoxon signed-rank test, ^****P<0.0001. MFE: minimum free energy; BP: biological process; MF: molecular function.