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. 2021 Mar 6;28(5):454–466. doi: 10.5551/jat.RV17048

Table 1. Influence of genetic deficiency or pharmacological inhibition of inflammasome effector mediators on experimental AAAs.

Mouse strain AAA model Gene knockout or pharmacological inhibitor Influence on experimental AAAs References
C57BL/6 Elastase infusion IL-1β -/- , IL-1R -/- or anakinra treatment •Attenuated AAA formation and reduced aortic macrophages and neutrophils [65] Johnston WF et al. Arterioscler Thromb Vasc Biol 33: 294-304, 2013.
C57BL/6 Lactobacillus casei cell-wall extracts IL-1α -/- , IL-1β -/- , or treatment with an antibody to IL-1α IL-1β •Protected AAA formation [77] Wakita D et al. Arterioscler Thromb Vasc Biol 36: 886-897, 2016.
C57BL/6 Calcium chloride IL-1β -/- , IL-1R -/- •No influence on AAA formation and proinflammatory macrophage polarization [75] Batra R et al. Arterioscler Thromb Vasc Biol 38: 457-463, 2018.
C57BL/6 Elastase infusion IL-1β -/-

•Reduced elastase-induced aortic diameter enlargement and aortic neutrophil infiltration

•Transferring wild type neutrophils restored aneurysmal aortic expansion in IL-1β knockout mice

[69] Meher AK et al. Arterioslcer Thromb Vasc Biol 38: 843-853, 2018.
C57BL/6 Ang II infusion IL-1Ra -/-

•Increased aneurysmal aortic diameter and aneurysm rupture

•Elevated inflammatory cytokines (IL-6 and TNF-α) and matrix metalloproteinases (MMP2 and MMP9) production

•Promoted smooth muscle degradation and macrophage infiltration

•Anti-IL-1β antibody treatment inhibited aortic dilation and inflammation in Ang II-infused IL-1Ra -/- mice

[85] Isoda K et al. Int J Cardiol 270: 221-227,

2018.

C57BL/6

Ang II infusion and treatment with β

-aminopropionitrile

IL-18 -/-

•Reduced aneurysm diameter and rupture

•Reduced macrophage infiltration and phenotype switch towards anti- inflammatory macrophages

•Inhibited OPN-induced inflammation and matrix metalloproteinases activation

[79] Suehiro C et al.

Atherosclerosis 289:

14-20, 2019.

ApoE-/- Ang II infusion NCC -/- or IL-18R -/-

•Attenuated aneurysmal aortic dilation and reduced aneurysm rupture

•Reduced inflammatory cell infiltration and the levels of MMP2, MMP9, IL-6, IFN-γ and TNF-α

[73] Liu CL et al. Eur J Heart 41: 2456-2468,

2020.

AAA: Abdominal aortic aneurysm. Ang II: Angiotensin II. ApoE: Apolipoprotein E. IFN: Interferon. IL: Interleukin. IL-1Ra: IL-1 receptor antagonist. MMP: Matrix metalloproteinase. R: Receptor. TNF: Tumor necrosis factor. NCC: Na-Cl co-transporter. OPN: Osteopontin. -/-: Deficient mice