Table 1. Influence of genetic deficiency or pharmacological inhibition of inflammasome effector mediators on experimental AAAs.
| Mouse strain | AAA model | Gene knockout or pharmacological inhibitor | Influence on experimental AAAs | References |
|---|---|---|---|---|
| C57BL/6 | Elastase infusion | IL-1β －/－ , IL-1R －/－ or anakinra treatment | •Attenuated AAA formation and reduced aortic macrophages and neutrophils | [65] Johnston WF et al. Arterioscler Thromb Vasc Biol 33: 294-304, 2013. |
| C57BL/6 | Lactobacillus casei cell-wall extracts | IL-1α －/－ , IL-1β －/－ , or treatment with an antibody to IL-1α IL-1β | •Protected AAA formation | [77] Wakita D et al. Arterioscler Thromb Vasc Biol 36: 886-897, 2016. |
| C57BL/6 | Calcium chloride | IL-1β －/－ , IL-1R －/－ | •No influence on AAA formation and proinflammatory macrophage polarization | [75] Batra R et al. Arterioscler Thromb Vasc Biol 38: 457-463, 2018. |
| C57BL/6 | Elastase infusion | IL-1β －/－ |
•Reduced elastase-induced aortic diameter enlargement and aortic neutrophil infiltration •Transferring wild type neutrophils restored aneurysmal aortic expansion in IL-1β knockout mice |
[69] Meher AK et al. Arterioslcer Thromb Vasc Biol 38: 843-853, 2018. |
| C57BL/6 | Ang II infusion | IL-1Ra －/－ |
•Increased aneurysmal aortic diameter and aneurysm rupture •Elevated inflammatory cytokines (IL-6 and TNF-α) and matrix metalloproteinases (MMP2 and MMP9) production •Promoted smooth muscle degradation and macrophage infiltration •Anti-IL-1β antibody treatment inhibited aortic dilation and inflammation in Ang II-infused IL-1Ra －/－ mice |
[85] Isoda K et al. Int J Cardiol 270: 221-227, 2018. |
| C57BL/6 |
Ang II infusion and treatment with β -aminopropionitrile |
IL-18 －/－ |
•Reduced aneurysm diameter and rupture •Reduced macrophage infiltration and phenotype switch towards anti- inflammatory macrophages •Inhibited OPN-induced inflammation and matrix metalloproteinases activation |
[79] Suehiro C et al. Atherosclerosis 289: 14-20, 2019. |
| ApoE－/－ | Ang II infusion | NCC －/－ or IL-18R －/－ |
•Attenuated aneurysmal aortic dilation and reduced aneurysm rupture •Reduced inflammatory cell infiltration and the levels of MMP2, MMP9, IL-6, IFN-γ and TNF-α |
[73] Liu CL et al. Eur J Heart 41: 2456-2468, 2020. |
AAA: Abdominal aortic aneurysm. Ang II: Angiotensin II. ApoE: Apolipoprotein E. IFN: Interferon. IL: Interleukin. IL-1Ra: IL-1 receptor antagonist. MMP: Matrix metalloproteinase. R: Receptor. TNF: Tumor necrosis factor. NCC: Na-Cl co-transporter. OPN: Osteopontin. -/-: Deficient mice