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A graphic representation of the key findings of the current investigation. Binding of HN to Aβ reduces the prefibrillar and fibrillar oligomers in the absence or presence of AChE, reducing apoptosis and increasing cell survival. IGFBP-3 binds HN and blocks its interaction with Aβ, resulting in increased prefibrillar and fibrillar oligomer formation and leading to increased apoptosis and decreased cell survival.
