Table 1: Ongoing Clinical Trials Involving CRISPR-Edited ACT for Cancer.

Information was gathered through Clinicaltrials.gov unless otherwise noted.

Citation	ClinicalTrials.gov identifier	Company/Institution	CRISPR gene targets	Cell therapy details	Summary/Status
Trials for which reports are available
Stadtmauer et al. (35)	NCT03399448	University of Pennsylvania	PDCD1, TRAC, TRBC	NY-ESO-1 TCR T cells	Results demonstrate that multiplexed CRISPR/Cas9 genome editing is feasible at clinical scale and suggest acceptable safety
Xinxin Wang et al.a	NCT04264078	Xinqiao Hospital of Chongqing	TRAC, CD7	CD7 CAR T cells	Results demonstrate deep clinical responses and an acceptable safety profile; GvHD was not observed in any patients treated with allogeneic CAR T cells
Lu et al. (29)	NCT02793856	Sichuan University	PDCD1	Peripheral blood lymphocytes	Results for patients given CRISPR/Cas9 PD-1-edited T cells suggest that CRISPR editing in adoptively transferred T cells is feasible in a clinical setting and generally safe
Trials for which reports are not yet available
	NCT03545815	Chinese PLA General Hospital	TCR, PDCD1	Mesothelin CAR T cells	Recruiting
	NCT04035434	CRISPR Therapeutics AG	B2M, TRAC	CD19 T cells	Recruiting
	NCT03747965	Chinese PLA General Hospital	PDCD1	Mesothelin CAR T cells	Recruiting
	NCT03081715	Hangzhou Cancer Hospital	PDCD1	Peripheral blood lymphocytes	Completed
	NCT04037566	Xijing Hospital	HPK1	CD19 CAR T cells	Recruiting
	NCT03690011	Baylor College of Medicine	CD7	CD7 CAR T cells	Not yet recruiting
	NCT04244656	CRISPR Therapeutics AG	?	B-cell maturation antigen T cells	Recruiting
	NCT03044743	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	PDCD1	Epstein-Barr virus-specific T cells	Recruiting
	NCT03398967	Chinese PLA General Hospital	?	CD19 and CD20 or CD22 CAR T cells	Recruiting
	NCT03166878	Chinese PLA General Hospital	TCR, B2M	CD19 CAR T cells	Recruiting

^a111th Annual Meeting of the American Association for Cancer Research (abstract available at: https://www.abstractsonline.com/pp8/#!/9045/presentation/10760)