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. 2021 May 28;9:685522. doi: 10.3389/fcell.2021.685522

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Copyright © 2021 Jia, Zhai, Qu, Ye, Zhao, Liu, Zhang and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Animal model experiment process. (B) H&E staining of thyroid tissue, (a) control, (b) Thyroiditis, (c) Metformin treated, (d) lymphocyte infiltration scores (ns, not significant). (C) TGAb expression in plasma and spleen index comparison. (D) Mouse thyroid tissue, (a) control, (b) Thyroiditis, (c) Metformin treated.