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. 2021 May 28;9:645375. doi: 10.3389/fbioe.2021.645375

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Copyright © 2021 Chen, Li, Zhang, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRMT5 promoted ESCC cell migration and invasion. (A) Wound-healing assay indicated that knocking down PRMT5 expression effectively inhibited cell mobility. The photographs were taken at the magnification of ×40. (B,C) Transwell migration and invasion assay showed that knocking down PRMT5 expression suppressed the migration and invasion abilities of ECA109 and KYSE150 cells. The photographs were taken at the magnification of ×200. (D) The expression levels of MMP-2 and MMP-9 were analyzed in ECA109 and KYSE150 cells. GAPDH was used as a control. Bars indicate the mean ± SEM, *P < 0.05, **P < 0.01 vs. control siRNA. PRMT5, protein arginine methyltransferase 5; ESCC, esophageal squamous cell carcinoma.