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. 2021 Jun 10;9:45. doi: 10.1186/s40364-021-00303-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Regulation network of differentially expressed lncRNAs. A Genome sites with a set of abnormally adjacent lncRNAs. B The top 10 significant GO groups enriched with adjacent genes. C The pie chart shows the most significant classes of adjacent genes. D The adjacent genes EGFL7, AGPAT2, JPH1, PTPN2, and TANK were significantly upregulated when we knocked down their neighbouring lncRNAs TCONS_00026679, uc002ubt.1, ENST00000522339 and ENST00000411904 in Jurkat cells