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. 2021 Jun 10;12:335. doi: 10.1186/s13287-021-02398-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Lack of effect of BNN-20 administration on the main neurogenic zones of the postnatal brain. A Dot plot of numbers of BrdU+ cells per length and B representative immunofluorescence images of BrdU+ cells in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus [n = 3 per group. Scale bar 200 μm. Error bars are SDs. a: p < 0.05 compared to the respective WT group, using two-way ANOVA (p = 0.002, F = 18.881) followed by LSD post hoc test]. C Histogram of the cell density of transient neural progenitors (Ascl1), proliferating cells (PCNA+), neuroblasts (Dcx+), and Dcx+/PCNA+ cells in the SEZ [n = 2 mice per group. a: p < 0.05 compared to WT sal. Analysis was performed by two-way ANOVA (PCNA+ comparison: p = 0.009, F = 8.902 for genotype, PCNA+/Dcx + comparison: p = 0.001, F = 18.030 for genotype) followed by LSD post hoc test. Error bars are SDs.]. D Representative immunofluorescence images of PCNA+ and Dcx+ cells within the SEZ of WT or wv mice post-administration of BNN-20 or saline (sal) during P14–P60 [scale bars = 200 μm]