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. 2021 Jun 10;12:335. doi: 10.1186/s13287-021-02398-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Contribution of the SEZ in dopaminergic neurogenesis in the SNpc. A–D Characteristic images of DiI+/TH+ newborn dopaminergic neurons in the SNpc (indicated by white arrows), derived from the SEZ neurogenic niche of the adult brain [scale bar = 50 μm]. E Profile of DiI+ dopaminergic (TH+) neurons of the SNpc in wild-type (WT) and “weaver” (wv) mice, after BNN-20 [or saline (sal)] administration, based on co-expression of FoxA2 [n = 2 mice per group. Error bars are SEMs. Statistical analysis was performed using two-way ANOVA followed by Bonferroni post hoc test]. F Representative triple immunofluorescence image depicting a cluster of DiI+/TH+ neurons in a WT BNN-20 SNpc. The white arrow indicates a TH+/DiI+/FoxA2+ cell and the yellow arrow a TH+/DiI+/FoxA2− dopaminergic neuron [scale bar = 50 μm]