Table 2.
AUCs for Various MRS Metabolites Stratified by 9-Month Survival
| Region | Metabolite | 1 day AUC (95% CI) |
2 week AUC (95% CI) |
4 week AUC (95% CI) |
8 week AUC (95% CI) |
16 week AUC (95% CI) |
|---|---|---|---|---|---|---|
| Tumor | NAA/Cho |
0.92
(0.78,1) |
0.75
(0.54,1) |
0.60 (0.41, 0.78) |
0.71
(0.52, 0.90) |
0.85
(0.68, 1) |
| Lac/NAA |
0.83
(0.64,1) |
1
(1,1) |
0.76
(0.69, 0.92) |
0.76
(0.58, 0.93) |
0.76
(0.56, 0.96) |
|
| Periphery | NAA/Cho |
0.75
(0.53, 0.97) |
0.88
(0.69,1) |
0.75
(0.57, 0.93) |
0.75
(0.57, 0.93) |
0.88
(0.73, 1) |
| Lac/NAA | 0.55 (0.30, 0.79) |
1
(1,1) |
0.68 (0.51, 0.85) |
0.61 (0.41,0.80) |
0.72
(0.51, 0.93) |
The table illustrates AUCs of NAA/Cho and Lac/NAA in the tumor and tumor periphery with 95% CI at different time points. Effective classifications defined by a lower bound of the 95% CI greater than 0.5 are bolded.