Figure 4.

Proposed mechanism of increased survival of GBM IDH-WT, RB1-mutant patients based on prior studies. GBM IDH-WT patients with RB1 loss-of-function mutations have an increased survival through replication stress and DNA damage, which leads to DNA repair inability in the tumor cells. In addition, RB1 loss of function is correlated with increased tumor-infiltrating lymphocytes (right). These might be the cause of the increased survival compared to RB1-WT, GBM IDH-WT patients (left). RB1 loss of function is represented by the red “X.”