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. 2021 Apr 23;3(1):vdab063. doi: 10.1093/noajnl/vdab063

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Progressively increased atypia and hypercellularity within irradiated PNs after SI. H&E-stained sections of normal nerve and nerve sheath tumors arising after focal spinal irradiation. 10X magnification (top) and 20× (bottom) magnification images shown. (A) normal nerve from a wildtype mouse. (B) PN showing diffuse enlargement and replacement of the nerve fascicle by spindle cells and collagen. (C) CNF with more prominent hypercellularity. (D) ANNUBP. (E) Low-grade MPNST infiltrating skeletal muscle.