Figure 5.

Chemotherapy, Radiotherapy, and Epigenetic therapy which facilitates immunogenic cell death increase antigen presentation enhances cross-priming of dendritic cells, and decreases PDL-1 expression on tumor cells activates the antitumor immune response. Drugs that target Tregs, tumor-associated macrophages (TAM), and myeloid-derived suppressor cells block immunosuppression and enhance T effector T cell function to convert immunosuppressive tumor microenvironment into the immune-stimulatory environment.