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PIK3CA protein (Human, 1068 aa) and mutations. Top, mutations found in common and combined lymphatic malformations (LM, LVM, CLVM). Bottom, mutations found in patients with PROS (KTS, CLOVES, unclassified PROS). See distribution in Table 1. Shared mutations in bold. Hotspot mutations underlined. ABD, p85α-binding domain; RBD, Ras-binding domain; C2, C2-PIK3C-type domain; H, helical domain; K, kinase domain
