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. Author manuscript; available in PMC: 2021 Jun 11.
Published in final edited form as: Br J Surg. 2019 Jun 13;106(9):1187–1196. doi: 10.1002/bjs.11181

Table 2.

Univariable and multivariable analysis of clinicopathologic factors associated with overall survival.

Characteristic Univariate analysis Multivariate analysis

5-yr (%) p-value OR 95% CI p-value

Type of gastrectomy 0.002 0.067
 Distal 60.8 Ref
 Total/proximal 42.5 1.882 0.980–3.613

Tumour size, cm 0.001 0.666
 ≤4.0 60.2 Ref
 >4.0 41.2 0.913 0.603–1.381

Tumour location <0.001 0.026
 Lower third 62.2 Ref
 Middle third 48.8 0.780 0.408–1.493 0.453
 Upper third 44.1 0.915 0.437–1.917 0.814
 More than one part 0.00 2.916 1.049–8.104 0.040

Lauren type <0.001 0.812
 Intestinal 62.0 Ref
 Diffuse 38.2 0.910 0.446–1.855 0.795
 Mixed/unknown 48.5 0.801 0.384–1.671 0.554

Differentiation type <0.001 0.076
 Differentiated 67.7 Ref
 Undifferentiated/unknown 37.2 1.803 0.940–3.458

Vascular invasion <0.001 0.416
 Yes 37.0 Ref
 No 65.3 1.215 0.760–1.943

Perineural invasion <0.001 0.843
 Yes 39.8 Ref
 No 63.8 0.956 0.614–1.489

Treatment effect 0.020 0.354
 0–49% 46.4 Ref
 50–89% 56.9 1.085 0.665–1.769 0.744
 90–100% 61.7 1.899 0.793–4.550 0.150

AJCC ypTNM stage <0.001 0.127
 I 82.1 Ref
 II 62.9 1.487 0.480–4.605 0.491
 III 23.9 2.678 0.740–9.693 0.133

Modified ypTNM stage <0.001 0.004
 I 86.5 Ref
 II 74.1 2.349 0.420–13.154 0.331
 IIIA 45.3 3.506 0.542–22.682 0.188
 IIIB 9.7 8.585 1.224–60.222 0.031