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. 2021 May 28;9:679325. doi: 10.3389/fcell.2021.679325

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Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global inactivation of Meis2 affects inner ear formation. (A–D) Meis2^flox/flox; Sox2^Cre/+ mutants show severely reduced otic vesicles (ov) at embryonic day 9 (E9) in comparison to controls as revealed by Pax2 and Dlx5 riboprobes. (E,F) Sections reveal widespread cyclinD1 immunoreactivity in the neural tube (nt) and the otic placode (op) of controls and mutants. Note the reduced size of the otic placode in the mutant. (G–L) Flatmounts of the hindbrain reveal an unaltered expression of Hoxb1, Fgf3 and MafB riboprobes in the indicated rhombomeres (r) in Meis2^flox/flox; Sox2^Cre/+ mutants in comparison to control embryos. ba, branchial arch.