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. 2021 May 28;9:679325. doi: 10.3389/fcell.2021.679325

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Copyright © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of otic vesicle markers in Meis2^flox/flox; Pax2^Cre/+ mutants. Expression of the indicated markers was detected via mRNA in situ hybridization (E–H,K,L) or immunohistochemistry (C,D,I,J,M,N). (A,B) Bright field image of controls and mutants showing a reduced sized otic vesicle at E10,5. (C,D) Sections at E10 reveal widespread pH3 immunoreactivity in the otic vesicles (circumference indicated by stippled lines) of controls and mutants. (E–L) No changes in the spatial domains of the otic markers (borders indicated by arrows) is observed in the mutants at E9 (E–H) and E10 (I–L). (M,N) At E11 the ventral domain of Sox2 expression is smaller in mutants correlating with the reduced sized dimensions of the otic vesicle at this stage. Scale bars in (C,E,I): 50 μm; in (K): 100 μm and in (M): 75 μm.