TABLE 7.
Thrombolytic drugs | Molecular weight (kDa) | Number of amino acids | Domain structure | Fibrin specificity | Plasminogen activation |
---|---|---|---|---|---|
Streptokinase | 47 | 414 | 3 (α, β, and γ) | No | Indirect |
Staphylokinase | 15.5 | 136 | 2 domains | Yes | Indirect |
Nattokinase | 27.7 | 275 | 1 domain | Yes | Direct |
Urokinase-type plasminogen activator | 54-33 | 411 | 3 (GFD, KD, P) | No | Direct |
Recombinant tissue-type plasminogen activator | 70 | 527 | 5 (F, EGF, K1, K2, P) | Yes | Direct |