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Clearance of α-syn occurs through three major ways. If the α-syn is in the unfolded dimer or the small oligomer state it undergoes proteasomal degradation (A) or chaperone mediated autophagy (B), in presence of HSc70, α-syn is engulfed by lysosome through LAMP2A receptor. Else, if the aggregation is higher than oligomer state, it prefers macro autophagy (C), where it forms autophagosome, which is engulfed by the lysosome. This figure was drawn using Motifolio.
