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. 2021 May 28;9:664168. doi: 10.3389/fcell.2021.664168

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Copyright © 2021 Chen, Tan, Hu, Liu, Peng, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Notch signaling pathway in chondrocytes. When Notch signaling is produced, Notch ligand of adjacent cells bind to Notch receptor, then the receptor is cleaved by γ-secretase to release the NICD. Next, NICD enters the nucleus and interact with RBPjk to induce the target genes expression (Hes and Hey). Afterward, the expression of Sox9 is inhibited, whereas the expression of Runx2 is increased. Besides, Notch also can induce the expression of p57 via BMP/Smad signaling to promote chondrocyte hypertrophy and suppress chondrocyte proliferation.